Combine harvesters can disperse weed seed, spreading them within a field and from field to field. Harvest Weed Seed Control (HWSC) is a method of weed control that concentrates, removes, or kills weed seeds that are retained on weed plants at the time of crop harvest. HWSC can be used to reduce the soil seedbank and thus future weed problems. It can also aid in herbicide resistance management, by killing or removing seeds produced by weeds that have escaped herbicidal control. This publication overviews current options to adopt HWSC and research results from Virginia.